S100A1’s Single Cysteine Is an Indispensable Redox-Switch for the Protection against Diastolic Calcium Wavesin Cardiomyocytes

The authors uncovered that S100A1 was endogenously glutathionylated in the adult heart in vivo. To prevent glutathionylation of S100A1, they generated S100A1 variants that were unresponsive to oxidative posttranslational modifications.