S100A1’s Single Cysteine Is an Indispensable Redox-Switch for the Protection against Diastolic Calcium Wavesin Cardiomyocytes

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The authors uncovered that S100A1 was endogenously glutathionylated in the adult heart in vivo. To prevent glutathionylation of S100A1, they generated S100A1 variants that were unresponsive to oxidative posttranslational modifications.
[American Journal of Physiology-Heart and Circulatory Physiology]
Abstract