SIV Infection and ARV Treatment Reshape the Transcriptional and Epigenetic Profile of Naïve and Memory T Cells In Vivo

Investigators used RNAseq and ATACseq to study the transcriptomics and epigenetic landscape of longitudinally sampled naïve and memory CD4+ and CD8+ T cells in two species of non-human primates prior to simian immunodeficiency viruses (SIV) infection, during chronic SIV infection, and after administration of antiretrovirals.