Acidic Nanoparticles Restore Lysosomal Acidification and Rescue Metabolic Dysfunction in Pancreatic β-Cells under Lipotoxic Conditions

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The authors reported that treatment with tetrafluorosuccinic acid nanoparticles restored lysosomal acidification, autophagic function, and mitochondrial activity, thereby improving the pancreatic function in INS-1 cells and high-fat-diet mice with lipid overload.
[ACS Nano]
AbstractGraphical Abstract