Analysis of Three Characterization Assays Reveals ddPCR of LIN28A as the Most Sensitive for the Detection of Residual Pluripotent Stem Cells in Cellular Therapy Products

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Investigators compared three in vitro assays: qPCR, ddPCR, and RT-LAMP using spike-in samples from three independent experiments, each spiked with different PSC lines into a background of primary fibroblasts, to determine their detection limit in measuring a commonly used PSC marker, LIN28A.
[Cytotherapy]
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