EGFR and HER2 Hyper-Activation Mediates Resistance to Endocrine Therapy and CDK4/6 Inhibitors in ER+ Breast Cancer

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Cetuximab treatment overcame tumor resistance to fulvestrant and abemaciclib in FAR and EGFR-overexpressing breast cancer spheroids and xenografts. Likewise, patient-derived organoids from individuals with ER + mBC, progressing on palbociclib, exhibited up-regulation of EGFR and HER2 pathways.
[Cancer Letters]
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