Enhancing IgA-Mediated Neutrophil Cytotoxicity Against Neuroblastoma by CD47 Blockade

In vitro killing assays showed enhanced IgA-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) by neutrophils targeting neuroblastoma cell lines and organoids in comparison to IgG. Notably, when combined with CD47 blockade, both IgG and IgA therapy were enhanced, though the combination with IgA resulted in the greatest improvement of ADCC.
[Journal For Immunotherapy of Cancer]
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