Pancreatic Epithelial IL-17/IL-17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis

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Deletion of IL-17RA from the pancreatic epithelial compartment, but not from hematopoietic, resulted in delayed premalignant lesions initiation and progression and increased CD8+ cytotoxic T cells infiltration to the tumor microenvironment, investigators reported.
[Cancer Immunology Research]
Abstract