Loss of the Proteasomal Deubiquitinase USP14 Induces Growth Defects and a Senescence Phenotype in Colorectal Cancer Cells

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Using an inducible USP14 knockout system in colon cancer cells, investigators reported that USP14 depletion impeded cellular proliferation, induced cell cycle arrest, and led to a senescence-like phenotype.
[Scientific Reports]
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