Loss of the Proteasomal Deubiquitinase USP14 Induces Growth Defects and a Senescence Phenotype in Colorectal Cancer Cells

Using an inducible USP14 knockout system in colon cancer cells, investigators reported that USP14 depletion impeded cellular proliferation, induced cell cycle arrest, and led to a senescence-like phenotype.
[Scientific Reports]
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