The DNA Methyltransferase Inhibitor 5-Aza-4′-Thio-2′-Deoxycytidine Induces C>G Transversions and Acute Lymphoid Leukemia Development

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Researchers investigated the therapeutic potential of 5-Aza-4’-thio-2’-deoxycytidine (ATC) in a murine transplantation model of myelodysplastic syndrome. ATC treatment led to transformation of transplanted wild-type bone marrow nucleated cells into lymphoid leukemia.
[Cancer Research]
Abstract