MLK3 Promotes Prooncogenic Signaling in Hepatocellular Carcinoma via TGFβ Pathway

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To understand MLK3’s role in HCC, researchers utlized carcinogen-induced HCC model and compared between wild-type and MLK3 knockout mice. Their studies showed that MLK3 kinase activity is upregulated in HCC, and MLK3 deficiency alleviates HCC progression.
[Oncogene]
Abstract