Selective Depletion of Tumor-Infiltrating Regulatory T Cells with BAY 3375968, a Novel FC-Optimized Anti-CCR8 Antibody

The chemokine receptor 8 (CCR8) was found to be predominantly expressed on Tregs within the tumor microenvironment of both humans and mice, representing a unique target for selective depletion of tumor-residing Tregs.
[Clinical and Experimental Medicine]
Full Article