Selective Depletion of Tumor-Infiltrating Regulatory T Cells with BAY 3375968, a Novel FC-Optimized Anti-CCR8 Antibody

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The chemokine receptor 8 (CCR8) was found to be predominantly expressed on Tregs within the tumor microenvironment of both humans and mice, representing a unique target for selective depletion of tumor-residing Tregs.
[Clinical and Experimental Medicine]
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