Pancreas-Directed AAV8-hSPINK1 Gene Therapy Safely and Effectively Protects against Pancreatitis in Mice

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Scientists explored the potential of adeno-associated virus type 8 (AAV8)-mediated overexpression of human SPINK1 (hSPINK1) for pancreatitis therapy in mice. The effectiveness of AAV8-hSPINK1 on pancreatitis prevention and treatment was studied in three mouse models.
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Abstract