Pancreas-Directed AAV8-hSPINK1 Gene Therapy Safely and Effectively Protects against Pancreatitis in Mice

Scientists explored the potential of adeno-associated virus type 8 (AAV8)-mediated overexpression of human SPINK1 (hSPINK1) for pancreatitis therapy in mice. The effectiveness of AAV8-hSPINK1 on pancreatitis prevention and treatment was studied in three mouse models.