Gene Therapy Targeting Key Beta Cell Regulators as a Potential Intervention for Diabetes

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The authors summarize the roles of pancreatic and duodenal homeobox 1, v-Maf musculoaponeurotic fibrosarcoma oncogene family protein A, and paired box 6 in determining beta cell function and diabetes development. They also explore the potential of gene therapy that delivers these beta cell regulators as therapeutic interventions to rescue beta cell function in diabetes.
[EMBO Molecular Medicine]
Abstract