ASXLs Binding to the PHD2/3 Fingers of MLL4 Provides a Mechanism for the Recruitment of BAP1 to Active Enhancers

Researchers reported a novel function of the plant homeodomain (PHD) 2 and 3 fingers of mixed lineage leukemia 4 and 3 that bind to additional sexcombs like (ASXL) 2, a component of the polycomb repressive H2AK119 deubiquitinase complex.