Tumor Cell-Derived Serglycin Promotes IL-8 Secretion of CAFs in Gastric Cancer

Scientists revealed the mechanisms of the preferential production of IL-8 by cancer-associated fibroblasts (CAFs) in gastric cancer. Serglycin secreted by tumour cells activated the CD44/c-Myc pathway to upregulate lysine[K]-specific demethylase 5B expression, thereby promoting IL-8 production in CAFs.