Suppression of Smooth Muscle Cell Inflammation by Myocardin-Related Transcription Factors Involves Inactivation of TANK-Binding Kinase 1

Researchers tested if myocardin-related transcription factors suppressed inflammation also by targeting cGAS-STING signaling. Interrogation of a transcriptomic dataset where myocardin was overexpressed using a panel of 56 cGAS-STING cytokines showed the panel to be repressed.