Tead4 and Tfap2c Generate Bipotency and a Bistable Switch in Totipotent Embryos to Promote Robust Lineage Diversification

0
59
The authors showed that TEAD4 and TFAP2C accelerated the loss of totipotency. These two factors paradoxically promoted and inhibited Hippo signaling before lineage diversification.
[Nature Structural & Molecular Biology]
Full Article