Human Gastric Cancer Progression and Stabilization of ATG2B through RNF5 Binding Facilitated by Autophagy-Associated CircDHX8

Researchers investigated the mechanism underlying the role of hsa_circ_003899 (circDHX8) in the malignancy of gastric cancer (GC). CircDHX8 was identified as upregulated and shown to enhance the malignant progression in GC cells by promoting cellular autophagy.