C-terminally Phosphorylated p27 Activates Self-Renewal Driver Genes to Program Cancer Stem Cell Expansion, Mammary Hyperplasia and Cancer

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Investigators reported that CSCN abundance is transcriptionally regulated by C-terminally phosphorylated p27. Mechanistically, this arises through p27 co-recruitment with STAT3/CBP to gene regulators of CSC self-renewal including MYC, the Notch ligand JAG1, and ANGPTL4.
[Nature Communications]
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