Co-Stimulation of CD28/CD40 Signaling Molecule Potentiates CAR-T Cell Efficacy and Stemness

Scientists developed dual T/B cell co-stimulatory molecules in CAR-T cells to enhance intense tumoricidal activity and persistence. CD19.28.40z CAR-T cells promoted pNF-κB and pRelB downstream signaling while diminishing NFAT signaling upon antigen exposure.