HNF4A and HNF1A Exhibit Tissue Specific Target Gene Regulation in Pancreatic Beta Cells and Hepatocytes

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To better define the pleiotropic gene regulatory roles of HNF4A and HNF1A, researchers generated a comprehensive genome-wide map of their binding targets in pancreatic and hepatic cells using ChIP-Seq. Functional follow-up highlighted a potential role for HAAO and USH1C as regulators of beta cell function.
[Nature Communications]
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