PLD1 Is a Key Player in Cancer Stemness and Chemoresistance: Therapeutic Targeting of Cross-Talk Between the PI3K/Akt and Wnt/β-Catenin Pathways

Crosstalk involving the phospholipase D and Wnt/β-catenin pathways promotes the progression of colorectal cancer and glioblastoma multiforme and reduced the sensitivity of cancer cells to standard therapies.