Therapeutic Efficacy of Mexiletine for Long QT Syndrome Type 2: Evidence From Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes, Transgenic Rabbits, and Patients

Heart rate–corrected field potential duration, a surrogate for QTc, was measured in human induced pluripotent stem cells from two patients with long QT syndrome type 2 before and after mexiletine using a multiwell multi-electrode array system.