Adaptation to an Acid Microenvironment Promotes Pancreatic Cancer Organoid Growth and Drug Resistance

0
31
The authors adapted mouse organoids from normal pancreatic duct and early pancreatic cancer from extracellular pH 7.4 to 6.7, representing acidic niches. They investigated whether tumor acidosis interacted with driver mutations to exacerbate cancer hallmarks.
[Cell Reports]
Full ArticleGraphical Abstract