Optimized rAAV8 Targeting Acinar KLF4 Ameliorates Fibrosis in Chronic Pancreatitis via Exosomes-Enriched Let-7s Suppressing Pancreatic Stellate Cells Activation

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Krüppel-like factor 4 (KLF4) was significantly upregulated in damaged acinar cells (ACs) and was established as the key molecule that switches ACs from pancreatic stellate cells (PSC)-suppressor to PSC-activator.
[Molecular Therapy]
AbstractGraphical Abstract