Drug Evaluation of Parkinson’s Disease Patient-Derived Midbrain Organoids Using Mesoporous Au Nanodot-Patterned 3D Concave Electrode

Midbrain organoids generated from Parkinson’s disease patient-derived iPSCs with gene mutations or normal midbrain organoids were positioned on the developed 3D concave electrode. The 3D concave electrode showed a 1.4 times higher electrochemical signal of dopamine compared to the bare gold electrode.