Tissue-Resident Memory T Cells Break Tolerance to Renal Autoantigens and Orchestrate Immune-Mediated Nephritis

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Scientists followed the fate and function of pathogen-activated autoreactive CD8 T cells that were specific for a renal autoantigen. THey demonstrated that recently activated splenic CD8 T cells developed a hybrid phenotype in the context of renal autoantigen cross-presentation, combining hallmarks of activation and T cell dysfunction.
[Cellular & Molecular Immunology]
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