GPIbα CAAR T Cells Function Like a Trojan Horse to Eliminate Autoreactive B Cells to Treat Immune Thrombocytopenia

The authors engineered human T cells to express a chimeric autoantibody receptor (CAAR) with GPIbα constructed into the ligand-binding domain fused to the CD8 transmembrane domain and CD3ζ-4-1BB signaling domains.