Off-the-Shelf CAR-NK Cells Targeting Immunogenic Cell Death Marker ERp57 Execute Robust Antitumor Activity and Have a Synergistic Effect With ICD Inducer Oxaliplatin

To target ERp57, a VHH phage display library was used for screening ERp57-targeted nanobodies (Nbs). A candidate Nb with high binding affinity to both human and mouse ERp57 was used for constructing CAR-NK cells.