CNS-Wide Repopulation by Hematopoietic-Derived Microglia-Like Cells Corrects Progranulin Deficiency in Mice

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Bone marrow transplant of progranulin-deficient mice conditioned with busulfan and PLX3397 restored progranulin in the brain and eyes and normalized brain lipofuscin storage, proteostasis, and lipid metabolism.
[Nature Communications]
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