ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma

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Researchers identified the receptor tyrosine kinase Ror2 as marker of a gastric metaplasia-like identity in pancreas neoplasms. Ablation of Ror2 in a mouse model of pancreatic tumorigenesis promoted a switch to a gastric pit cell identity that largely persisted through progression to the classical subtype of PDAC.
[Cancer Discovery]
Abstract