A Classical Epithelial State Drives Acute Resistance to KRAS Inhibition in Pancreas Cancer

Using genetically engineered mouse models and patient-derived xenografts, researchers discovered that basal PDAC cells were highly sensitive to KRAS inhibitors. Employing fluorescent and bioluminescent reporter systems, they longitudinally tracked cell-state dynamics in vivo and revealed a rapid, KRAS inhibitor-induced enrichment of the classical state.