Early Blood Immune Molecular Alterations in Cynomolgus Monkeys with a PSEN1 Mutation Causing Familial Alzheimer’s Disease

Researchers designed a CRISPR/Cas9 system to achieve precise genomic deletion of exon 9 in cynomolgus monkeys using two guide RNAs targeting the 3′ and 5′ intron sequences of PSEN1 exon 9.
[Alzheimers & Dementia]
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