ICOS-expressing Regulatory T Cells Influence the Composition of Antitumor CTL Populations

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Using an experimental melanoma lung metastasis model, scientists found that Treg cell–specific ICOS knockout reduced the overall tumor burden compared with Cre control mice, with increased CD4+-to-Treg cell and CD8+-to-Treg cell ratios in the tumor.
[Journal of Immunology]
Abstract