Subchronic Intranasal Lipopolysaccharide Exposure Induces Pulmonary Autoimmunity and Glomerulonephritis in NZBWF1 Mice

Investigators determined how subchronic intranasal (IN) lipopolysaccharide (LPS) instillation influenced autoimmunity and glomerulonephritis development in lupusprone NZBWF1 female mice. Briefly, mice were IN-instilled with vehicle or E. coli LPS twice weekly for 5 wk, followed by necropsy.