Nicotinamide N-Methyltransferase Inhibition Mimics and Boosts Exercise-Mediated Improvements in Muscle Function in Aged Mice

Since human hallmarks of sarcopenia were recapitulated in aged mice, researchers treated mice from 22 to 24 months of age with Nicotinamide N-methyltransferase inhibitor, intensive exercise, or a combination of both, and compared skeletal muscle adaptations.