CL429 Enhances the Renewal of Intestinal Stem Cells by Upregulating TLR2-YAP1

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Knockdown of YAP1 significantly attenuated the radioprotective effect of CL429 on intestinal organoids, indicating that CL429-mediated intestinal radioprotection is dependent on YAP1.
[International Immunopharmacology]
AbstractGraphical Abstract