IL-13Rα2/TGF-β Bispecific CAR-T Cells Counter TGF-β–Mediated Immune Suppression and Potentiate Anti-Tumor Responses in Glioblastoma

Investigators engineered a single-chain, bispecific CAR targeting IL-13Rα2 and TGF-β, which programed tumor-specific T cells to convert TGF-β from an immunosuppressant to an immunostimulant.