Chimeric Antigen Receptor-Induced Antigen Loss Protects CD5.CART Cells from Fratricide without Compromising On-Target Cytotoxicity

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Researchers demonstrated that the expression of a CAR targeting CD5, a prominent pan-T cell antigen, inducef rapid internalization and complete loss of the CD5 protein on T cells, protecting them from self-targeting.
[Cell Reports Medicine]
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