Novel Immunomodulatory Properties of Adenosine Analogs Promote Their Antiviral Activity Against SARS-CoV-2

In the case of remdesivir, investigators showed that immunomodulatory properties are due to its metabolite, GS-441524, acting as an adenosine A2A receptor antagonist. Their findings supported a new rationale for the design of next-generation antiviral agents with dual – immunomodulatory and intrinsic – antiviral properties.