Necroptosis Enhances ‘Don’t Eat Me’ Signal and Induces Macrophage Extracellular Traps to Promote Pancreatic Cancer Liver Metastasis

Using RNA sequencing and multiplex immunofluorescence, investigators reported elevated expression of mixed lineage kinase domain-like pseudo-kinase (MLKL) and enhanced necroptosis pathway in PDAC from early liver metastasis T-stage patients comparing with non-metastatic patients.