Vasohibin Inhibition Improves Myocardial Relaxation in a Rat Model of Heart Failure with Preserved Ejection Fraction

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Scientists explored whether increased microtubule network (MTN) detyrosination contributed to impaired diastolic function in the ZSF1 obese rat model of Heart failure with preserved ejection fraction (HFpEF) and designed a small-molecule vasohibin inhibitor to ablate MTN detyrosination in vivo.
[Science Translational Medicine]
Abstract