RhoA/ROCK-TAZ Axis Regulates Bone Formation within Calvarial Trans-Sutural Distraction Osteogenesis

Scientists utilized pre-osteoblast-specific Ras homolog gene family member A (RhoA) deletion mice to establish an in vivo calvarial trans-sutural distraction model and an in vitro mechanical stretch model for pre-osteoblasts isolated from neonatal mice.