Tomivosertib Reduces Ectopic Activity in Dorsal Root Ganglion Neurons from Patients with Radiculopathy

Using cultured dorsal root ganglion neurons recovered during thoracic vertebrectomy surgeries, investigators showed that inhibition of mitogen-activated protein kinase interacting kinase (MNK) with tomivosertib reversibly suppressed spontaneous activity in human sensory neurons that were likely nociceptors based on size and action potential characteristics associated with painful dermatomes within minutes of treatment.