C-JUN Overexpressing CAR-T Cells in Acute Myeloid Leukemia: Preclinical Characterization and Phase I Trial

Scientists found that CAR T cells exposed to myeloid leukemia showed impaired activation and cytolytic function, accompanied by impaired antigen receptor downstream calcium, ZAP70, ERK, and C-JUN signaling, compared to those exposed to B cell leukemia.