Cancer Stem Cells Release Interleukin-33 within Large Oncosomes to Promote Immunosuppressive Differentiation of Macrophage Precursors

Researchers examined how IL-33 derived from CSCs facilitated the development of an immunosuppressive microenvironment. CSCs with high NRF2 activity redistributed nuclear IL-33 to the cytoplasm and released IL-33 as cargo of large oncosomes.