Epirubicin Induces Cardiotoxicity through Disrupting ATP6V0A2-Dependent Lysosomal Acidification and Triggering Ferroptosis in Cardiomyocytes

The authors investigated mechanisms underlying ferroptosis-driven epirubicin-induced cardiotoxicity (EIC). Epirubicin triggered ferroptosis both in vivo and in cultured cardiomyocytes, and pretreatment with ferroptosis inhibitor, Ferrostatin-1 alleviated EIC.