Disseminated Tuberculosis Is Associated with Impaired T Cell Immunity Mediated by Non-canonical NF-κB Pathway

Researchers with disseminated tuberculosis had depleted Th1, Tc1 and Tc17 cell subsets, and IFNG was the most down-regulated gene in both CD4 and CD8 T cells. Gene Ontology analysis showed that non-canonical NF-κB signaling pathway, including NFKB2 and RELB genes, were significantly down-regulated and were probably associated with disseminated tuberculosis.