Kmt2c Restricts G-CSF-Driven HSC Mobilization and Granulocyte Production in a Methyltransferase-Independent Manner

The authors showed that Kmt2c deletions hypersensitize murine HSCs and myeloid progenitors to granulocyte colony-stimulating factor (G-CSF), as evidenced by increased HSC mobilization and enhanced granulocyte production from granulocyte-monocyte progenitors.