Targeting of Immune Checkpoint Regulator V-Domain Ig Suppressor of T Cell Activation (VISTA) with 89Zr-Labelled CI-8993

To determine the pharmacokinetics and biodistribution of CI-8993 in patients, researchers aimed to develop 89Zr-labelled CI-8993 and validate PET imaging and quantitation in preclinical models prior to a planned human bioimaging trial.